Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity
نویسندگان
چکیده
منابع مشابه
Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity
Most blood vessels are surrounded by adipose tissue. Similarly to the adventitia, perivascular adipose tissue (PVAT) was considered only as a passive structural support for the vasculature, and it was routinely removed for isolated blood vessel studies. In 1991, Soltis and Cassis demonstrated for the first time that PVAT reduced contractions to noradrenaline in rat aorta. Since then, an importa...
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Under physiological conditions, perivascular adipose tissue (PVAT) attenuates agonist-induced vasoconstriction by releasing vasoactive molecules including hydrogen peroxide, angiotensin 1-7, adiponectin, methyl palmitate, hydrogen sulfide, NO and leptin. This anticontractile effect of PVAT is lost under conditions of obesity. The central mechanism underlying this PVAT dysfunction in obesity is ...
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ژورنال
عنوان ژورنال: International Journal of Endocrinology
سال: 2013
ISSN: 1687-8337,1687-8345
DOI: 10.1155/2013/402053